The reference site for Tylosin

Tylosin is an antibiotic and a bacteriostatic feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms.

WHAT IS Tylosin?

Tylosin is an antibiotic of the macrolide class developed for veterinary use.

It is made naturally by the bacterium Streptomyces fradiae and acts to inhibit bacterial protein synthesis by inhibiting the 50S ribosome, a cellular structure only certain bacteria have and use to make internal proteins.

Tylosin is licensed for use as a broad spectrum antibiotic for injectable or oral use in treatment of infection (e.g. respiratory tract and skin infections) in livestock. In small animals, tylosin has been used for its anti-inflammatory and antibiotic properties to treat colitis. It may also be used as a growth promoter in food animals.

Tylosin is sold under the brand name Tylan®.

Brand Name(s): Tylan
CAS nº: 1401-69-0
(ty lo sin)

 

Product Info

The sections below will provide you with more specific information and guidelines related to tylosin and its correct use. Please read them carefully.

FDA Information

Tylosin has been approved by the US FDA, and is also widely used in the European Union (EU), Australia, New Zealand and several other countries.

In 1999, the EU banned the use of tylosin for growth promotion in animals. However, the EU still endorses tylosin for therapeutic use and has also approved it for a wide variety of species.

Please visit the official site of the FDA for further information.

Why is this medication prescribed?

Tylosin is an antibiotic of the macrolide class developed for veterinary use.

It is made naturally by the bacterium Streptomyces fradiae and acts to inhibit bacterial protein synthesis by inhibiting the 50S ribosome, a cellular structure only certain bacteria have and use to make internal proteins.

Tylosin is licensed for use as a broad spectrum antibiotic for injectable or oral use in treatment of infection (e.g.  respiratory tract and skin infections) in livestock. In small animals, tylosin has been used for its anti-inflammatory and antibiotic properties to treat colitis. It may also be used as a growth promoter in food animals.

Other uses for this medicine

This medication has not been approved for any alternative uses other than those mentioned in the product information section.

Dosage and using this medicine

Tylosin is available in oral powder or injectable form.

Give this medication to the animal as directed by your veterinarian. Read the label carefully.

Tylosin may be administered to calves, orally in the milk replacer, at a dose of 40 mg/kg bw and to cattle by intramuscular injection at a dose of 4-10 mg/kg bw.

In pigs, tylosin may be administered in the drinking water at a dose of 25mg/kg bw, in the feed at a dose of 3-7 mg/kg bw, or by intramuscular at a dose of 2-10 mg/kg bw for the prevention and control of diseases such as swine dysentery and enzootic pneumonia.

Tylosin is administered to poultry in the drinking water at a dose equivalent to 35 mg/kg bw.

Tylosin is also authorised as a feed additive in accordance with Council Directive 70/524/EEC: the substance may be incorporated into pig feed at concentrations in the range of 5-20 mg/kg feed for animals up to  6 months of age and 10-40 mg/kg for animals up to 4 months age.

Honey bees: mix 200 milligrams tylosin in 20 grams confectioners’/powdered sugar. Use immediately. Apply (dust) this mixture over the top bars of the broo  chamber once weekly for 3 weeks.

What special precautions should I follow?

BEFORE ADMINISTERING TYLOSIN:

Tylosin should not be used in animals with known hypersensitivity or allergy to tylosin or other macrolide antibiotics.

Make sure to tell your veterinarian what other medication you are giving the animal.

Additionally, the drug digitalis can potentially interact with tylosin, and alter its effectiveness.

Milk for human consumption must not be taken from a cow during treatment with tylosin.

Discontinue use in cattle 21 days before slaughter, and 14 days for swine.

Do not use in pregnant animal, nor in lactating dairy cattle. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Adverse reaction, including shock and death, may result from overdose in baby pigs. Do not attempt injection into pigs weighing less than 25 pounds . It is recommended that tylosin injection 50 mg/ml be used in pigs weighing less than 25 pounds. If tylosin medicated drinking water is used as a follow-up treatment for swine dysentery, the animal should receive feed containing 40 to 100 grams of tylosin per ton for 2 wekkes to assure depletion of tissue residues.

Furthermore, do not mix Tylan® injection with other injectable solutions as this may cause precipitation of the active ingredients. Importantly, never administer to horses or other equines as injection of tylosin in equines has been fatal.

Special precautions to be taken by the person administering the product to animals:

People with known hypersensitivity to macrolide antibiotics should avoid contact with the product. Avoid skin contact. In case of contact with skin or eyes, rinse abundantly with fresh water. If irritation occurs and persists seek medical advice. Wear protective gloves and a mask when handling the product. Wash hands after use.

Accidental self-injection may give rise to pain. In case of self-injection seek medical advice immediately and show the package insert or the label to the physician.

What should I do if I forget a dose?

Give the dose as soon as possible. If it is almost time for the next dose, skip the missed dose, and continue with the regular schedule.

Never give the animal two doses at once.

What side effects can this medication cause?

While there is definite side effect potential in large animal species, some other animals (e.g. dogs) can tolerate very high doses of tylosin with no adverse effects. The biggest problem with small animal use seems to be the especially foul taste of tylosin which necessitates formulation into capsules, which is usually done by a compounding pharmacy.

Tylosin’s main side effects include mild stomach upset, lack of appetite and diarrhea. If these symptoms continue, contact your veterinarian.

Other side effects may occur. If you notice anything unusual in the animal’s normal behaviour, contact your veterinarian.

Note: tylosin may falsely elevate certain liver blood tests (ALT and AST).

What storage conditions are needed for this medicine?

Keep tylosin in the container it came in, tightly closed. Ground all equipment containing material, and keep in a cool, well-ventilated place and away from heat and direct sunlight.

Any unused product or waste material should be disposed of in accordance with national requirements.

Note: tylosin may be combustible at high temperature.

In case of an emergency/overdose

Tylosin is relatively safe in most overdose situations.

The LD50 in pigs is greater than 5 g/kg orally, and approximately 1 g/kg IM. However, shock and death have been reported in baby pigs overdosed with tylosin.

Dogs are re­ported to tolerate oral doses of 800 mg/kg. Long-term (2 year) oral administration of up to 400 mg/kg produced no organ toxicity in dogs.

In cases of human injection, contact your local physician immediately. Furthermore, the manufacturer has emergency phone number to assist in dealing with exposure: 1-800-428-4441.

Product Images

PICTURES OF TYLOSIN PRODUCTS

Below you will find images and specific information on the principal types of tylosin that exist, including their respective brand name(s), strength, inscription codes, manufacturers and/or distributors.

The information below includes general information and guidelines for animal keeprs and farmers administering this medication, and should never be used to substitute professional medical advice that can be provided by a qualified veterinarian.

 

Name: TYLOSIN
Strength(s): 200 ML
Imprint: TYLOSIN INJECTION
Manufacturer: VEYX PHARMACEUTICALS

Name: TYLOSIN
Strength(s): 200 ML
Imprint: TYLOSIN 200
Manufacturer: EAGLE VET. TECH. CO.

Name: TYLOSIN
Strength(s): 200 ML
Imprint: TYLOSIN INJECTION
Manufacturer: BOEHRINGER INGELHEIM

Name: TYLOSIN
Strength(s): 250 ML
Imprint: TYLOSIN INJECTION
Manufacturer: BOEHRINGER INGELHEIM

Name: TYLAN®
Strength(s): 10 GM
Imprint: TYLAN 10
Manufacturer: ELANCO

Name: TYLAN®
Strength(s): 40 GM
Imprint: TYLAN 40
Manufacturer: THOMAS LABORATORIES

Name: TYLAN®
Strength(s): 100 GM
Imprint: TYLAN
Manufacturer: ELANCO

Name: TYLOSIN
Strength(s): 900 UMG
Imprint: TYLOSIN EPV
Manufacturer: LUKANG PHARMACEUTICALS

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